Microtubules

Can microtubules act as a good pharmaceutical target?

Microtubules are cognise as tubuline polymers initiated in the cellular teleph atomic number 53 cytoplasm of
eukaryotic cells. They sustain a hollow core group surrounded by a cell wall make up of 13
tubuline molecules which are stacked up beside each other. Tubuline is a recognised
as a globular protein and has two dissimilar subunits such as ?-tubuline and
?-tubuline. These dimers add on to the ends of a microtubule allowing the molecule to ontogenesis in size (Campbell & Reece, 2004). GTP irreversibly binds to the GTP- rachis site positi id on ?-tubuline where it does not become hydrolysed. On the other hand GTP reversibly binds to the binding site on ?-tubuline where hydrolysis converts GTP into GDP (W.H.Freeman & company, 2000). Microtubules are involved in various different cellular activities such as flagellar and ciliary motion, maintenance and determination of the shape of a cell, cell incision and chromosome movement. Because they create movement within the cell, both the cell as a whole and its subcellular components corroborate the ability to move from one place to another (Kleinsmith & Kish, 1988)

[pic](W.H.Freeman & company, 2000)

Patients who suffer from Parkinsons disease have a protein called alpha-synuclein in their brain.



The toxic effects from this protein damages neurons in Parkinsons disease. Study shows that these neurons can be kept protected by inhibiting the action of an enzyme called SIRT2. Microtubules help transport objects within cells and it is known that SIRT2 acts on a huge component of microtubule in clubhouse to inhibit its action. Research has shown that inhibition of SIRT2 has lead to microtubule-dependent transportation of alpha-synuclein into deep quantities. On the other hand, it is capable of strengthening current microtubules that have been destabilised by misfolded alpha-synuclein (The medical news, 2007).

Microtubules have dynamic stability allowing one end polymerise and the other to depolymerise....If you want to get a full essay, order it on our website: Orderessay



If you want to get a full essay, wisit our page: write my essay .